Warren Greatrex believes leading mare La Bague Au Roi can bag her third career pattern victory as she takes on eight rivals in the Olgb.com Mares' Hurdle (2:05).
The six-year-old won three times as a novice hurdler last season, including a listed success at Newbury in November.
She was well fancied in the Mares Novice at the Festival, but found Mullins' Let's Dance sixteen lengths too good finishing seventh.
She went one place better against the boys in the Mersey Novice Hurdle, before capping off the year with a routine win at Huntingdon.
With plenty of options available for the mares, her trainer is expecting a promising season over hurdles and fences.
“She did very well for us last season,” said the Berkshire-based trainer.
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Let's Dance beat Le Bague Au Roi to Mares Novice glory, meaning Willie Mullins has won both runnings of the race since it began in 2016
“She’s come back in and looks really well. I think she likes Wetherby and she seems to have good course form there, she won’t mind the ground.
"She seems in great form and this looks a great point to start her off at, to carry on over hurdles and then fences after."
Tom George's Miss Night Owl renews her rivalry with Alan King's Giveaway Glance, only a head separated the pair when they met at Stratford last month.
Lady Buttons won three races on the trot for Philip Kirby last season, but the seven-year-old finished last on her previous outing on the flat.
Intense Tango, Hello Sweetie and Graceful Legend are joined by Late Night Lilly who lines up for Dan Skelton.